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Therapeutic Angiogenesis with Sound Waves.

Tomohiko Shindo¹, Hiroaki Shimokawa¹

¹Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Annals of Vascular Diseases

|June 30, 2020

Summary

Low-intensity pulsed ultrasound (LIPUS) therapy shows promise for treating ischemic heart disease and dementia. This innovative sound wave therapy promotes angiogenesis, improving conditions like myocardial ischemia and cognitive impairment.

Keywords:

angiogenesis mechanotransduction nitric oxide shock wave ultrasound

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Area of Science:

Biomedical Engineering
Cardiovascular Research
Neuroscience

Background:

Severe ischemic heart disease (IHD) has a poor prognosis, highlighting the need for effective angiogenic therapies.
Current treatments for dementia are limited, necessitating novel therapeutic approaches.

Purpose of the Study:

To develop and evaluate low-intensity pulsed ultrasound (LIPUS) therapy for ischemic heart disease (IHD) and cognitive impairment.
To investigate the potential of LIPUS as a minimally invasive angiogenic therapy.

Main Methods:

Developed low-energy extracorporeal cardiac shock wave therapy and later, low-intensity pulsed ultrasound (LIPUS) therapy.
Validated efficacy in animal models of chronic myocardial ischemia and dementia (Alzheimer's disease, vascular dementia).
Conducted clinical trials for refractory angina and are currently running a prospective multicenter trial for severe angina pectoris.

Main Results:

Demonstrated that LIPUS therapy enhances angiogenesis through endothelial mechanotransduction, improving myocardial ischemia in animal models.
Confirmed efficacy of LIPUS in improving cognitive impairment in mouse models of Alzheimer's disease and vascular dementia.
Previous work confirmed efficacy of cardiac shock wave therapy in animal models and patients with refractory angina.

Conclusions:

LIPUS therapy is a promising, minimally invasive approach for treating ischemic heart disease by promoting angiogenesis.
LIPUS therapy also shows potential for improving cognitive impairment in dementia models, suggesting broader therapeutic applications.
Sound wave-based therapies represent a novel strategy for addressing significant unmet medical needs in cardiovascular disease and neurodegenerative disorders.