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Area of Science:

  • Neurology
  • Neuropsychology
  • Epileptology

Background:

  • Cognitive deficits are common in people with epilepsy (PWE).
  • Limited validated neurocognitive tests and multidisciplinary teams in Brazilian epilepsy clinics hinder evaluation.
  • The Brief Cognitive Battery-Edu (BCB-Edu) is a potential screening tool.

Purpose of the Study:

  • To correlate Brief Cognitive Battery-Edu (BCB-Edu) scores with epilepsy characteristics in 371 PWE.
  • To assess the effectiveness of BCB-Edu as a screening test for cognitive impairment in adults with epilepsy.

Main Methods:

  • A clinical and cognitive assessment was performed on 371 PWE (aged >18) using the MMSE and BCB-Edu.
  • Epilepsy characteristics were correlated with BCB-Edu data.
  • Cognitive data from PWE were compared to 95 healthy individuals (NC).

Main Results:

  • PWE demonstrated significantly lower cognitive performance compared to the NC group.
  • Cognitive performance varied based on epilepsy characteristics.
  • Age and polytherapy (use of >1 antiepileptic drug) were identified as predictive factors for cognitive impairment.

Conclusions:

  • Worse cognitive performance is prevalent across various domains in PWE.
  • Cognitive impairment in PWE is associated with specific epilepsy characteristics.
  • The BCB-Edu is an effective screening test for cognitive assessment in adult PWE.