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SERS Barcode Libraries: A Microfluidic Approach.

Semih Sevim1, Carlos Franco1, Xiang-Zhong Chen2

  • 1Institute of Chemical and Bioengineering ETH Zurich Vladimir Prelog Weg 1 Zurich 8093 Switzerland.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 30, 2020
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This study introduces a microfluidic device for highly sensitive surface-enhanced Raman spectroscopy (SERS) detection. The technology enables simultaneous, contamination-free detection of multiple analytes, including single molecules, with reusable substrates.

Area of Science:

  • Analytical Chemistry
  • Nanotechnology
  • Spectroscopy

Background:

  • Microfluidic technologies offer advanced capabilities for surface-enhanced Raman spectroscopy (SERS).
  • Current limitations include challenges in creating reconfigurable and reusable devices for multiplexed detection.
  • Existing methods struggle with precise analyte localization and preventing cross-contamination in microfluidic SERS.

Purpose of the Study:

  • To develop a microfluidic method for precise spatial control of multiple SERS substrates within a single channel.
  • To enable simultaneous, contamination-free detection of multiple analytes at extremely low concentrations.
  • To create reconfigurable and reusable SERS devices for enhanced analytical applications.

Main Methods:

  • A microfluidic-based approach was employed to achieve spatial control over SERS substrate localization.
Keywords:
SERS barcodingmicroengineered SERS substratesmicrofluidicsmultiple detection

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  • Analyte transport was meticulously managed to specific detection points, preventing cross-contamination.
  • SERS substrates were rationally designed, allowing for rapid etching and reconstruction for reusability.

    • Main Results:

    • The technology demonstrated exquisite control over analyte transport within the microfluidic channel.
    • Simultaneous detection of multiple analytes was achieved in a single channel without cross-contamination.
    • Single-molecule detection was realized, with sensitivities down to 10-14 m.
    • The SERS substrates proved to be reconfigurable and reusable through rapid etching and reconstruction.

    Conclusions:

    • This microfluidic SERS platform provides unprecedented spatial control for multiplexed analyte detection.
    • The developed method overcomes limitations in reconfigurability and reusability for microfluidic SERS devices.
    • The technology facilitates highly sensitive, simultaneous, and contamination-free analysis of multiple analytes, including single molecules.