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The Roles of Glycans in Bladder Cancer

Yuli Jian1, Zhongyang Xu1, Chunyan Xu1

  • 1Department of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, China.

Frontiers in Oncology
|June 30, 2020
PubMed

Insights

Abnormal glycans, crucial molecules in cell functions, are linked to bladder cancer. Understanding their role could lead to new diagnostic biomarkers and treatments for this common malignancy.

Area of Science:

  • Biochemistry and Molecular Biology
  • Oncology
  • Glycoscience

Background:

  • Bladder cancer presents significant global morbidity and mortality.
  • High recurrence rates and poor prognosis necessitate novel therapeutic targets and biomarkers.
  • Glycans, essential biomacromolecules, are involved in critical cellular processes like signaling and adhesion.

Purpose of the Study:

  • To review the role of glycans in bladder cancer.
  • To discuss the clinical utility of glycans for bladder cancer diagnosis and treatment.
  • To highlight abnormal glycans as potential diagnostic biomarkers.

Main Methods:

  • Literature review focusing on glycan alterations in bladder cancer.
  • Analysis of glycan functions in cellular processes relevant to cancer.
  • Evaluation of existing research on glycan-based biomarkers and therapies.

Main Results:

  • Glycans play fundamental roles in cell adhesion, signaling, and protein processing.
  • Aberrant glycosylation patterns are observed in bladder cancer.
  • Specific glycan structures show potential as diagnostic and prognostic indicators.

Conclusions:

  • Glycans are implicated in the pathogenesis of bladder cancer.
  • Altered glycan profiles represent promising biomarkers for early detection and personalized treatment strategies.
  • Further research into glycan biology is crucial for advancing bladder cancer care.
Keywords:
abnormal glycosylationbiomarkersbladder cancerglycansglycosyltransferases

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