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Multimodal 3D Printing of Phantoms to Simulate Biological Tissue
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Bioprinting of Multimaterials with Computer-aided Design/Computer-aided Manufacturing.

J M Lee1, S L Sing1, W Y Yeong1

  • 1Singapore Centre for 3D Printing, School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.

International Journal of Bioprinting
|June 30, 2020
PubMed
Summary

Multimaterials deposition in bioprinting enhances structural integrity using build/support configurations. A novel file preparation technique enables printing complex, freeform bioprinted constructs.

Keywords:
Additive manufacturingBioprintingComputer-aided designHydrogelRapid prototypingSupport structure generationThree-dimensional bioprintingThree-dimensional printing

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Area of Science:

  • Biotechnology
  • Materials Science
  • Tissue Engineering

Background:

  • Hydrogel-based bioprinting faces limitations in achieving structural integrity for complex constructs.
  • Multimaterials deposition offers a solution by enabling build/support strategies.

Purpose of the Study:

  • To explore the advantages of multimaterials deposition in bioprinting.
  • To improve the structural integrity of three-dimensional bioprinted constructs.
  • To introduce a file segmentation and preparation technique for freeform bioprinting.

Main Methods:

  • Utilizing a build/support configuration with rapid cross-linking hydrogels.
  • Employing chemical cross-linking for enhanced construct stability post-printing.
  • Developing and applying a file segmentation and preparation technique.

Main Results:

  • Demonstrated improved structural integrity of bioprinted constructs through multimaterials deposition.
  • Successfully bioprinted stable constructs using a combination of rapid cross-linking hydrogels.
  • Validated the effectiveness of the proposed file preparation technique for freeform structures.

Conclusions:

  • Multimaterials deposition is a key advancement in bioprinting, overcoming hydrogel limitations.
  • The build/support strategy with rapid cross-linking hydrogels enhances construct stability.
  • The novel file preparation technique facilitates the bioprinting of intricate, freeform structures.