Related Experiment Video

Updated: Dec 17, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

14.0K

The oncogenic role of MUC12 in RCC progression depends on c-Jun/TGF-β signalling

Sheng-Lin Gao1, Rui Yin2, Li-Feng Zhang1

  • 1Department of Urology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China.

Journal of Cellular and Molecular Medicine
|June 30, 2020
PubMed

Insights

MUC12 overexpression promotes kidney cancer (RCC) growth and invasion by activating TGF-β1 signaling via c-Jun. Targeting MUC12 offers a potential new therapy for metastatic RCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Renal cell carcinoma (RCC) is a prevalent global cancer.
  • Metastatic RCC presents limited therapeutic options, necessitating novel treatments.

Purpose of the Study:

  • To investigate the role of MUC12 in RCC progression.
  • To elucidate the underlying molecular mechanisms of MUC12 in RCC.

Main Methods:

  • Analysis of MUC12 expression in RCC patients.
  • In vitro studies on RCC cell growth and invasion.
  • Investigation of TGF-β1 signaling pathway and c-Jun involvement.

Main Results:

  • MUC12 is overexpressed in RCC and correlates with poor prognosis.
  • MUC12 overexpression enhances RCC cell growth and invasion.
  • MUC12-induced effects are mediated by TGF-β1 signaling and c-Jun transactivation.

Conclusions:

  • MUC12 plays a significant role in RCC progression.
  • The MUC12/c-Jun/TGF-β1 axis is a key driver of RCC.
  • Targeting MUC12 presents a promising therapeutic strategy for RCC.
Keywords:
MUC12TGF-β1c-Juninvasionrenal cell carcinoma

More Related Videos

RhoC GTPase Activation Assay09:58

RhoC GTPase Activation Assay

Published on: August 22, 2010

12.9K
An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells08:54

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

14.3K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
7.6K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.1K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.9K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.9K