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The Epidemiological and Clinical Characteristics of 81 Children with COVID-19 in a Pandemic Hospital in Turkey: an
Muhammet Furkan Korkmaz1, Esra Türe2, Bayram Ali Dorum3
1Department of Pediatrics, Bursa City Hospital, Bursa, Turkey. korkmazmfurkan@gmail.com.
Insights
COVID-19 presents milder in children than adults. Younger children (under five) experienced longer hospital stays and viral shedding after SARS-CoV-2 infection.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic caused by SARS-CoV-2 has had a global impact.
- Limited data exists on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pediatric populations.
Purpose of the Study:
- To investigate the epidemiological, laboratory, radiological, and treatment characteristics of pediatric patients with SARS-CoV-2.
- To understand the clinical course and outcomes of COVID-19 in children.
Main Methods:
- Retrospective analysis of 81 pediatric patients positive for SARS-CoV-2 via RT-PCR.
- Evaluation of symptoms, laboratory findings, imaging, and treatment data.
Main Results:
- Fever, cough, and fatigue were common symptoms. Abnormal labs included elevated CRP and D-dimer. Chest CT showed consolidation or ground-glass opacities in 8% of patients.
- Most children did not require intensive care. Median hospital stay was 5 days, and viral clearance took a median of 5 days.
- Younger children (≤5 years) had significantly longer hospital stays and time to SARS-CoV-2 negative RT-PCR results.
Conclusions:
- COVID-19 appears milder and presents differently in children compared to adults.
- Conservative diagnostic, clinical, and therapeutic strategies may be suitable for pediatric COVID-19 cases.
Background:
Coronavirus disease-2019 (COVID-19) pandemic has affected millions of people throughout the world since December 2019. However, there is a limited amount of data about pediatric patients infected with the disease agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods:
The epidemiological, laboratory, radiological, and treatment features of the pediatric patients who were positive for SARS-CoV-2 based on the reverse-transcription polymerase chain reaction (RT-PCR) test, were investigated retrospectively.
Results:
The median age of 81 children included in the study was 9.50 years (0-17.75 years). The most frequent symptoms at the time of admission were fever (58%), cough (52%), and fatigue or myalgia (19%). The abnormal laboratory findings in these cases were decreased lymphocytes (2.5%, n = 2), leucopenia (5%, n = 4), and increased lactate dehydrogenase (17.2%, n = 14), C-reactive protein (16%, n = 13), procalcitonin (3.7%, n = 3), and D-dimer (12.3%, n = 10). Three (4%) patients had consolidation in chest computed tomography, and three (4%) had ground-glass opacities. None of the patients needed intensive care except for the newborns. The median time to turn SARS-CoV-2 negative in the RT-PCR test was 5 (3-10) days. The median length of hospital stay was 5 (4-10) days. The time to turn SARS-CoV-2 negative in the RT-PCR test and the length of hospital stay were significantly longer for those aged five years or younger than others (P = 0.037, P = 0.01).
Conclusion:
Compared to adults, COVID-19 is milder and more distinctive in children. As a result, more conservative approaches might be preferred in children for the diagnostic, clinical, and even therapeutic applications.
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