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Creatine supplementation improves performance, but is it safe? Double-blind placebo-controlled study.

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Creatine monohydrate supplementation is safe for athletes, showing no adverse health effects. This study found no detrimental impact on blood, urine, or organ function in resistance training practitioners.

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Area of Science:

  • Sports Science
  • Nutritional Biochemistry
  • Exercise Physiology

Background:

  • Creatine is a popular ergogenic aid for athletes.
  • Concerns exist regarding creatine's safety for overall health.
  • This study investigates creatine monohydrate's health effects in resistance training.

Purpose of the Study:

  • To evaluate the safety of creatine monohydrate supplementation.
  • To assess effects on blood and urine health indicators.
  • To examine organ function in resistance training practitioners.

Main Methods:

  • Double-blind, placebo-controlled study design.
  • 18 male resistance training participants.
  • Supplementation with creatine monohydrate (0.3 g/kg/day for 7 days) or dextrosol.
  • Blood and urine analysis pre- and post-supplementation (41 parameters).

Main Results:

  • Creatine supplementation increased performance and body weight.
  • No adverse events were reported.
  • No significant changes in red/white blood cells, lipid profile, metabolic/urine markers, or hepatic/renal function were observed.

Conclusions:

  • Creatine monohydrate supplementation is safe for health.
  • No detrimental effects on physiological systems were detected in the study cohort.
  • Weight gain is an expected outcome of creatine supplementation.