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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Roles of Electrolytes: Calcium and Phosphate01:27

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Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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GPCRs Regulate Adenylyl Cylase Activity01:09

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Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
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Related Experiment Video

Updated: Dec 17, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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FGF23 and primary hyperparathyroidism: is there a link?

Stefana Catalina Bilha1, Alina Andreea Gatu2, Cristian Velicescu3

  • 1Endocrinology Department, "St. Spiridon" Hospital, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

Endokrynologia Polska
|June 30, 2020
PubMed
Summary

Fibroblast growth factor 23 (FGF23) levels do not appear to be a reliable indicator for assessing the severity of primary hyperparathyroidism (PHPT). FGF23 levels remained unchanged after treatment, suggesting limited prognostic value in PHPT patients.

Keywords:
FGF23PTHboneparathyroid adenomavitamin D

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
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Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
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Area of Science:

  • Endocrinology
  • Bone Metabolism

Background:

  • Limited and conflicting data exist on the role of fibroblast growth factor 23 (FGF23) in primary hyperparathyroidism (PHPT).
  • Evaluating FGF23's prognostic impact on the clinical and biochemical progression of PHPT is crucial.

Purpose of the Study:

  • To investigate the prognostic significance of FGF23 in patients with PHPT.
  • To assess the relationship between FGF23 levels and clinical/biochemical markers before and after surgical intervention for PHPT.

Main Methods:

  • Prospective study of 42 PHPT patients (age 30-80) undergoing parathyroidectomy.
  • Serum FGF23, PTH, 25(OH)D3, Ca, P, and bone turnover markers measured preoperatively and postoperatively.
  • Bone mineral density (BMD) assessed pre- and post-surgery.

Main Results:

  • Preoperative FGF23 levels were within the normal range and did not change significantly after surgery.
  • FGF23 levels remained stable up to 12 months post-surgery, despite normalization of PTH, Ca, and vitamin D.
  • Preoperative FGF23 showed a negative correlation with PTH but not with other biochemical or bone markers.

Conclusions:

  • The observed correlations between FGF23 and PTH in PHPT appear to be coincidental (epiphenomenon).
  • FGF23 evaluation and its dynamic changes do not provide significant information regarding PHPT severity.
  • FGF23 is not a recommended biomarker for assessing PHPT prognosis.