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Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
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Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

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Vancomycin C-Terminus Guanidine Modifications and Further Insights into an Added Mechanism of Action Imparted by a

Zhi-Chen Wu1, Michael D Cameron2, Dale L Boger1

  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.

ACS Infectious Diseases
|June 30, 2020
PubMed

Keywords:
antibiotic resistanceantimicrobial mechanisms of actionglycopeptide antibioticsguanidine modificationvancomycinvancomycin peripheral modification

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