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Updated: Dec 17, 2025
07:20
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
14.3K
Trichloro(Dinitrogen)Platinate(II)
Gilian T Thomas1, Sofia Donnecke1, Irina Paci1
1Department of Chemistry, University of Victoria, PO Box 1700 STN CSC, Victoria, British, Columbia, V8W 2Y2, Canada.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|June 30, 2020
Summary
Researchers have identified a novel platinum-dinitrogen complex, [PtCl3(N2)]−, using mass spectrometry. This groundbreaking discovery opens new avenues for organometallic chemistry involving platinum and dinitrogen.
Area of Science:
- Organometallic Chemistry
- Inorganic Chemistry
- Mass Spectrometry
Background:
- Zeise's salt, [PtCl3(H2C=CH2)]−, is the oldest known organometallic complex.
- Dinitrogen complexes of platinum and palladium are currently unknown.
Purpose of the Study:
- To investigate the possibility of forming dinitrogen complexes with platinum.
- To characterize the platinum-dinitrogen species generated in solution.
Main Methods:
- Electrospray ionization mass spectrometry (ESI-MS) of K2[PtCl4] solutions.
- Ion-mobility spectrometry and MS/MS experiments for ion identification.
- Computational analysis of platinum-dinitrogen bond strength and N-N bond length.
Main Results:
- Strong ions corresponding to [PtCl3(N2)]− were generated and detected.
- The identity of [PtCl3(N2)]− was confirmed and distinguished from isobaric species like [PtCl3(C2H4)]− and [PtCl3(CO)]−.
- Computational analysis revealed a gas-phase platinum-dinitrogen bond strength of 116 kJ mol−1, with a weakened N-N bond.
Conclusions:
- The formation and characterization of the platinum-dinitrogen complex [PtCl3(N2)]− represent a significant advancement.
- This finding challenges the previous understanding of dinitrogen coordination chemistry in platinum and palladium.
- The study provides crucial insights into the bonding and stability of platinum-dinitrogen interactions.
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