Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.2K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.2K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

728
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
728
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.5K
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

413
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
413
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

787
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
787
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

460
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
460

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Risk factors for bronchopleural complications after pneumonectomy].

Khirurgiia·2025
Same author

[Surgical heritage of academician Bogush L.K. and its influence on modern thoracic and phthisiatric surgery].

Khirurgiia·2024
Same author

[Pulmonary fibrosis after a new coronavirus infection - versions and controversies: A review].

Terapevticheskii arkhiv·2024
Same author

Possibilities of non-invasive diagnosis of fibrotic phenotype of interstitial lung diseases.

Terapevticheskii arkhiv·2023
Same author

[Miocarditis in Patients with COVID-19 Confirmed by Immunohistochemical].

Kardiologiia·2020
Same author

[Non - tuberculous mycobacteriosis of the lungs - diagnostic possibilities in the practice of the pulmonologist].

Terapevticheskii arkhiv·2020

Related Experiment Video

Updated: Dec 17, 2025

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.1K

[Immunological aspects of tuberculosis pathogenesis].

V J Gergert1, M M Averbakh1, A E Ergeshov1

  • 1Central TB Research Institute Department of Immunology.

Terapevticheskii Arkhiv
|June 30, 2020
PubMed
Summary

This review explores how the immune system influences tuberculosis (TB) pathogenesis and clinical manifestations. Understanding host-pathogen interactions is key to explaining diverse TB disease forms and outcomes.

Keywords:
immunitypathogenesistuberculosis

More Related Videos

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

810
Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.8K

Related Experiment Videos

Last Updated: Dec 17, 2025

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.1K
Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

810
Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.8K

Area of Science:

  • Immunology
  • Pathogenesis
  • Microbiology

Background:

  • Tuberculosis (TB) pathogenesis and adaptive immunity are well-documented.
  • The role of the immune system in clinically relevant TB abnormalities and diverse disease forms requires further investigation.
  • Clinical manifestations of TB result from the complex interaction between Mycobacterium tuberculosis (MTB) and the host's immune response.

Purpose of the Study:

  • To review the involvement of immune mechanisms in the pathogenesis of TB.
  • To discuss the immune system's role in the development and various manifestations of TB disease.
  • To highlight the importance of host-pathogen interactions in shaping TB outcomes.

Main Methods:

  • Literature review focusing on TB pathogenesis and immune responses.
  • Analysis of existing research on the interplay between Mycobacterium tuberculosis and the human host.
  • Synthesis of information regarding clinical manifestations and their underlying immune mechanisms.

Main Results:

  • Primary TB infection often leads to asymptomatic disease (88-90%) with potential spontaneous resolution.
  • A smaller percentage (10-12%) of primary infections progress to severe TB requiring treatment.
  • Host immunity, influenced by factors like infection dose and MTB virulence, dictates disease progression and outcomes.
  • Re-infection may present different pathogenic pathways compared to primary infection.

Conclusions:

  • The immune system plays a critical role in determining the clinical presentation and progression of TB.
  • Understanding the host immune response is essential for explaining the spectrum of TB disease.
  • Further research into immune mechanisms can elucidate TB pathogenesis and inform therapeutic strategies.