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[Antiviral therapy of chronic hepatitis C: 30 years success story]

D T Abdurakhmanov1, T P Rozina1, E N Nikulkina1

  • 1Tareev Clinic of Rheumatology Nephrology and Occupational Disease Sechenov First Moscow State Medical University.

Terapevticheskii Arkhiv
|June 30, 2020
PubMed

Insights

Hepatitis C antiviral therapy has seen major advances, with new direct-acting antiviral drugs now curing 90-95% of cases. This marks a significant achievement in treating hepatitis C virus infection.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) was identified 30 years ago.
  • Significant progress has been made in treating Hepatitis C.
  • HCV is now considered a nearly curable disease.

Purpose of the Study:

  • To review the evolution of Hepatitis C antiviral therapy.
  • To assess the efficacy of different treatment regimens.
  • To highlight recent advancements in HCV treatment.

Main Methods:

  • Literature review of Hepatitis C treatment development.
  • Analysis of efficacy data for various antiviral regimens.
  • Focus on direct-acting antiviral (DAA) therapies.

Main Results:

  • Hepatitis C treatment has advanced significantly over decades.
  • The last five years show the greatest progress due to DAAs.
  • Current DAA therapies achieve viral elimination in 90-95% of patients.

Conclusions:

  • Hepatitis C is now a highly curable disease.
  • Direct-acting antivirals represent a major breakthrough in HCV therapy.
  • Widespread use of DAAs offers a high chance of viral elimination.

Keywords:
HCVantiviral therapyinterferon alfapolymerase inhibitorsprotease inhibitorsribavirin

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