[Idiopatic Lobular Panniculitis as a common clinical problem].

Area of Science:

• Rheumatology
• Dermatology
• Internal Medicine

Background:

• Idiopathic lobular panniculitis (ILP) is a rare inflammatory condition affecting subcutaneous fat.
• Accurate diagnosis and classification of ILP subtypes are essential for appropriate management.
• Modern rheumatology practice requires a comprehensive understanding of ILP's diverse clinical presentations.

Purpose of the Study:

• To delineate the clinical and laboratory characteristics of various idiopathic lobular panniculitis (ILP) forms.
• To provide insights into the presentation of ILP within contemporary rheumatology settings.

Main Methods:

• Retrospective analysis of 67 patients diagnosed with panniculitis or erythema nodosum.
• Inclusion of general clinical examination, immunological, histological, and immunohistochemical studies.
• Utilization of chest computed tomography (CT) and tuberculin tests for comprehensive evaluation.

Main Results:

• Four distinct ILP forms were identified: nodular (n=30), plaque (n=10), infiltrative (n=15), and mesenteric (n=12).
• Disease duration varied significantly, with plaque form showing the shortest median duration (8 months) and infiltrative form the longest (66 months).
• Specific clinical features differentiated the forms, including fever, ulceration, and abdominal CT findings for mesenteric ILP.

Conclusions:

• The identified forms of ILP necessitate tailored treatment approaches in clinical practice.
• Enhanced physician awareness and further research are vital for timely ILP diagnosis and optimized treatment strategies.