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[Panniculitis in modern rheumatology]
O N Egorova1, B S Belov1, S I Glukhova1
1Nasonova Research Institute of Rheumatology.
Terapevticheskii Arkhiv
|June 30, 2020
Summary
This study analyzed 690 patients with panniculitis (Pn), finding idiopathic lobular Pn most common. Clinical and laboratory features of Pn associated with rheumatic diseases were identified, guiding modern treatment approaches.
Area of Science:
- Rheumatology
- Dermatology
- Internal Medicine
Background:
- Panniculitis (Pn) is an inflammatory condition affecting subcutaneous fat.
- Understanding its diverse clinical presentations and associations is crucial for accurate diagnosis and management.
- Rheumatic diseases (Rd) can manifest with or be associated with various forms of panniculitis.
Purpose of the Study:
- To investigate the clinical and laboratory characteristics of panniculitis in contemporary rheumatology practice.
- To identify features of panniculitis specifically associated with rheumatic diseases.
- To inform treatment strategies based on panniculitis type and underlying disease activity.
Main Methods:
- A cohort of 690 patients with panniculitis was studied over 10 years.
- Diagnostic algorithm included general clinical, immunological, histological examinations, and computed tomography.
- Tuberculin tests were also performed.
Main Results:
- Idiopathic lobular panniculitis was the most frequent type (49%), often linked to connective tissue diseases.
- Common associated rheumatic diseases included systemic lupus erythematosus and Behcet disease (13% each).
- Nodular panniculitis was the predominant form (64.02%); mesenteric panniculitis was specific to idiopathic lobular panniculitis.
Conclusions:
- Panniculitis presents with diverse clinical and laboratory features in modern rheumatology.
- Identifying panniculitis associated with rheumatic diseases is critical for patient management.
- Treatment approaches for panniculitis should be tailored to the specific type and the activity of the underlying rheumatic disease.
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