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B cells expressing CD5 are increased in Sjögren's syndrome
M Dauphinée1, Z Tovar, N Talal
1Clinical Immunology Section, Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas.
Arthritis and Rheumatism
|May 1, 1988
Summary
Increased CD5+ B cells are linked to autoimmune diseases like Sjögren
Area of Science:
- Immunology
- Cell Biology
Background:
- CD5 is a cell surface marker found on B cells.
- Elevated CD5+ B cells are observed in autoimmune conditions.
Purpose of the Study:
- To investigate the prevalence and significance of CD5+ B cells in primary Sjögren's syndrome (SS).
- To explore the relationship between CD5+ B cells, disease activity, and the risk of malignant lymphoma.
Main Methods:
- Flow cytometry to quantify CD5+ B cells in patients with primary SS, rheumatoid arthritis, systemic lupus erythematosus, and healthy controls.
- Longitudinal monitoring of CD5+ B cell levels over a 2-year period.
- Assessment of treatment effects (steroids, chemotherapy, irradiation) on CD5+ B cell counts.
Main Results:
- A significant increase in CD5+ B cells was found in 68% of primary SS patients and in rheumatoid arthritis patients.
- CD5+ B cell percentages were higher in SS (46%) and rheumatoid arthritis (47%) compared to systemic lupus erythematosus (24%) and normal subjects (26%).
- Two patients who developed malignant lymphoma showed normalization of CD5+ B cells after treatment, suggesting a link between these cells and disease status.
Conclusions:
- The study suggests a strong association between CD5+ B cell abnormalities and disease activity in primary SS.
- CD5+ B cells may play a role in the immunoregulatory processes of autoimmune diseases.
- The findings support the known predisposition to malignant lymphoma in SS patients and highlight the potential role of CD5+ B cells in this context.