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Updated: Dec 17, 2025

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Spatially antiviral dynamics determines HCV in vivo replication and evolution
Chentong Li1, Yingying Zhang2, Yicang Zhou2
1Guangdong Key Laboratory of Modern Control Technology, Guangdong Institute of Intelligent Manufacturing, Guangzhou, 510070, PR China; School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an 710049, PR China.
Abstract:
In this article, we establish HCV in a host growth partial-differential equation model to analyze the antiviral dynamics. A numerical method to analyze the basic reproductive number of this model is established and we find that for the without drug model, the diffusion rate of the virus and liver length have seldom influence on the growth of the virus. For the with drug model, we find the different pharmic factors have different effect on the virus. Based on this with drug model, we also introduce a semi-stochastic simulation method with which to analyze the virus in host evolution. Our result shows how different drugs can drive the virus in host evolution.
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