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Updated: Dec 17, 2025
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Differentiation of high-grade and low-grade intra-axial brain tumors by time-dependent diffusion MRI
Tomoko Maekawa1, Masaaki Hori2, Katsutoshi Murata3
1Department of Radiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Department of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Introduction:
Oscillating gradient spin-echo (OGSE) sequences enable acquisitions with shorter diffusion times. There is growing interest in the effect of diffusion time on apparent diffusion coefficient (ADC) values in patients with cancer. However, little evidence exists regarding its usefulness for differentiating between high-grade and low-grade brain tumors. The purpose of this study is to investigate the utility of changes in the ADC value between short and long diffusion times in distinguishing low-grade and high-grade brain tumors.
Material And Methods:
Eleven patients with high-grade brain tumors and ten patients with low-grade brain tumors were scanned using a 3 T magnetic resonance imaging with diffusion-weighted imaging (DWI) using OGSE and PGSE (effective diffusion time [Δeff]: 6.5 ms and 35.2 ms) and b-values of 0 and 1000 s/mm2. Using a region of interest (ROI) analysis of the brain tumors, we measured the ADC for two Δeff (ADCΔeff) values and computed the subtraction ADC (ΔADC = ADC6.5 ms - ADC35.2 ms) and the relative ADC (ΔADC = (ADC6.5 ms - ADC35.2 ms) / ADC35.2 ms × 100). The maximum values for the subtraction ADC (ΔADCmax) and the relative ADC (rADCmax) on the ROI were compared between low-grade and high-grade tumors using the Wilcoxon rank-sum test. A P-value <.05 was considered significant. The ROIs were also placed in the normal white matter of patients with high- and low-grade brain tumors, and ΔADCmax values were determined.
Results:
High-grade tumors had significantly higher ΔADCmax and rADCmax than low-grade tumors. The ΔADCmax values of the normal white matter were lower than the ΔADCmax of high- and low-grade brain tumors.
Conclusion:
The dependence of ADC values on diffusion time between 6.5 ms and 35.2 ms was stronger in high-grade tumors than in low-grade tumors, suggesting differences in internal tissue structure. This finding highlights the importance of reporting diffusion times in ADC evaluations and might contribute to the grading of brain tumors using DWI.
