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Effect of human recombinant interleukin 5 and G-CSF on eosinophil colony formation
H Enokihara1, S Nagashima, T Noma
1Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Immunology Letters
|May 1, 1988
Abstract:
Human recombinant (r) IL-5 was shown to have the activity to stimulate eosinophil (Eo) colony formation from human non-T, non-adherent bone marrow cells. The majority of these colonies were found to contain a small number of basophils, macrophages or neutrophils. Human rG-CSF, which alone did not stimulate Eo colony formation, showed an enhancing effect on Eo colony formation when added with IL-5. IL-5 seems to stimulate the proliferation and differentiation of CFU-Eo, while G-CSF acts on the early stage of eosinophilopoiesis.