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Lamellar Inclusions within Hyperplastic Endoplasmic Reticulum in Benign Mesothelial Cells.

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Cytoplasmic lamellar inclusions (LIs) in mesothelial cells are found in benign effusions, aiding differentiation from malignant cells. Electron microscopy revealed these inclusions within the rough endoplasmic reticulum.

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Area of Science:

  • Cytopathology
  • Cell Biology
  • Electron Microscopy

Background:

  • Mesothelial cells in effusion cytology can exhibit cytoplasmic lamellar inclusions (LIs).
  • The nature, function, and diagnostic significance of these LIs are not well understood.

Purpose of the Study:

  • To investigate the characteristics of LIs in mesothelial cells.
  • To determine the prevalence and diagnostic utility of LIs in routine cytological practice.

Main Methods:

  • Review of 102 reactive and 90 malignant effusions (including 63 mesotheliomas and 27 carcinomas).
  • Electron microscopy analysis of LIs in one effusion specimen.

Main Results:

  • LIs were identified in 14% of benign mesothelial cells in reactive effusions and 4% in malignant effusions with carcinomatosis.
  • LIs were absent in malignant mesothelioma effusions.
  • Electron microscopy showed LIs as lamellar and tubular structures within hyperplastic rough endoplasmic reticulum (rER).

Conclusions:

  • Cytoplasmic LIs within hyperplastic rER occur in up to 14% of effusions, exclusively in benign mesothelial cells.
  • These inclusions serve as an indirect morphological marker for benign effusions.
  • LIs can assist cytologists in distinguishing between reactive and malignant mesothelial cells.