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Galvanic Redox Potentiometry Based Microelectrode Array for Synchronous Ascorbate and Single-Unit Recordings in Rat

Huan Wei^1,2, Lijuan Li³, Jing Jin^1,2

¹Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China.

Analytical Chemistry

|July 1, 2020

Summary

This summary is machine-generated.

This study introduces a novel microelectrode array (MEA) combining galvanic redox potentiometry (GRP) and electrophysiology. This new sensor enables simultaneous real-time measurement of neurochemicals like ascorbate and neuronal electrical activity.

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Area of Science:

Neuroscience
Electrochemistry
Biosensing

Background:

Neuronal communication integrates chemical and electrical signals.
High-resolution techniques are needed to understand brain function.
Simultaneous measurement of neurochemicals and electrical activity is challenging.

Purpose of the Study:

To develop an integrated sensor for simultaneous neurochemical and electrical recording.
To assess the feasibility of galvanic redox potentiometry (GRP) for in vivo neurochemical sensing.
To correlate neurochemical dynamics with neuronal activity.

Main Methods:

Integration of GRP and electrophysiological recording on a 16-site microelectrode array (MEA).
Modification of an electrode with single-walled carbon nanotubes for enhanced ascorbate detection.
In vivo experiments in rat brains, including induction of spreading depression.

Main Results:

The GRP-based MEA demonstrated a linear relationship between open-circuit potential and logarithmic ascorbate concentration.
The sensor showed high selectivity for ascorbate against other electroactive species.
Successful synchronous real-time measurement of ascorbate release and neuronal electrical activity during spreading depression was achieved without interference.

Conclusions:

The developed GRP-based MEA enables simultaneous, high-resolution monitoring of neurochemical events and neuronal electrical activity.
This technology offers new possibilities for large-scale mapping of neurochemical patterns and their correlation with neuronal function.
The sensor provides a valuable tool for studying brain function and dysfunction in real-time.