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Visual Morbidity in Ocular Tuberculosis - Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6.
Rupesh Agrawal1,2,3,4, Dinesh Visva Gunasekeran1,2,3, Aniruddha Agarwal5
1National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
Ocular Immunology and Inflammation
|July 1, 2020
Summary
Ocular tuberculosis (OTB) causes significant visual impairment. While initial treatment may worsen vision, anti-tuberculosis treatment (ATT) leads to significant visual improvement over 24 months.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Public Health
Background:
- Ocular tuberculosis (OTB) is a significant cause of visual impairment globally.
- Understanding the natural history and clinical features of OTB is crucial for effective management.
Purpose of the Study:
- To examine the extent, natural history, and clinical features of visual impairment (VI) in patients with OTB.
- To evaluate the impact of anti-tuberculosis treatment (ATT) on visual outcomes in OTB patients.
Main Methods:
- Multi-center retrospective cohort study.
- Analysis of best-corrected visual acuity (BCVA) over 24 months of follow-up.
- Comparison of visual outcomes between patients treated with ATT and those not treated.
Main Results:
- A total of 302 patients were included; 175 had complete BCVA data for 2 years.
- Mean BCVA showed significant improvement at 12, 18, and 24 months (p < .001).
- ATT-treated patients had worse BCVA at 12-18 months but significant improvement by 24 months.
Conclusions:
- OTB is associated with substantial visual morbidity.
- ATT demonstrates a positive long-term impact on visual acuity in OTB patients.
- Further prospective studies are needed to confirm the causal link between OTB and visual loss.
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