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Published on: May 30, 2025
Infertility remains a top stressor despite the COVID-19 pandemic
Denis A Vaughan1, Jaimin S Shah1, Alan S Penzias1
1Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston MA, USA; Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston MA, USA; Boston IVF, Waltham MA, USA.
Insights
The stress of infertility remains a significant concern for patients, comparable to the psychological impact of the COVID-19 pandemic. This highlights the ongoing mental health challenges faced by individuals undergoing fertility treatments.
Area of Science:
- Reproductive Medicine
- Psychology
- Public Health
Background:
- The COVID-19 pandemic introduced unprecedented societal and economic uncertainty.
- Infertility patients often experience significant psychological distress.
Purpose of the Study:
- To assess the psychological impact of the COVID-19 pandemic on patients undergoing infertility treatment.
- To compare the stress levels associated with infertility versus the pandemic.
Main Methods:
- An anonymous cross-sectional online survey was distributed to patients at a US university-affiliated infertility practice.
- Respondents identified their top three stressors from a predefined list at three time points.
- 2202 non-pregnant female respondents were included in the final analysis.
Main Results:
- Infertility was consistently reported as the most frequent top stressor across all time points.
- The COVID-19 pandemic emerged as a significant stressor, ranking third in early March and becoming comparable to infertility stress by the time of writing (66% vs 63%).
- A notable percentage of patients (6%) believed infertility treatments, including in vitro fertilization (IVF), should be suspended during the pandemic.
Conclusions:
- The psychological burden of infertility remains a primary stressor for patients, even amidst the global COVID-19 pandemic.
- The stress associated with infertility is comparable in magnitude to the stress caused by the pandemic itself.
- The findings underscore the need for continued mental health support for infertility patients during public health crises.
Research Question:
What is the psychological impact of the COVID-19 pandemic on infertility patients?
Design:
An anonymous cross-sectional online survey was sent to patients who attended a large university-affiliated infertility practice in the USA between 1 January 2019 and 1 April 2020. At three different time-points respondents were asked to note their top three stressors, from a list of 10 commonly reported life stressors.
Results:
The questionnaire was sent to 10,481 patients, with 3604 responses (response rate 34%) received. A total of 2202 non-pregnant female respondents were included in the final analysis. One-third of respondents had a prior diagnosis of an anxiety disorder, and 11% reported taking anxiolytic medications; over one-quarter had a prior diagnosis of a depressive disorder and 11% reported taking antidepressant medications. At all three time-points, infertility was noted to be the most frequent top stressor. Coronavirus was noted to be the third most common stressor among the respondents in early March but, at the time of writing, is similar to that of infertility (63% and 66%, respectively). A total of 6% of patients stated that infertility treatment, including IVF, should not be offered during the COVID-19 pandemic.
Conclusion:
Despite the unprecedented global pandemic of COVID-19, causing economic and societal uncertainty, the stress of infertility remains significant and is comparable a stressor to the pandemic itself.
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