Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infertility in Males01:23

Infertility in Males

473
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
473
Spermatogenesis01:41

Spermatogenesis

119.7K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
119.7K
Spermatogenesis01:22

Spermatogenesis

8.4K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
8.4K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

3.8K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.8K
Infertility in Females01:28

Infertility in Females

3.5K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
3.5K
Menopause01:28

Menopause

3.5K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-reported prevalence and correlates of sex as self-injury in a Swedish high school population.

European child & adolescent psychiatry·2026
Same author

Donor-conceived adolescents' interest in obtaining information about their identity-release oocyte or sperm donor-results from the Swedish Study on Gamete Donation.

Human reproduction (Oxford, England)·2026
Same author

Stage-specific remodeling of wingless-related integration sites (WNT) signaling during oocyte-to-embryo transition in pigs.

Journal of animal science·2026
Same author

Correction: Exposure of <i>in vitro</i> maturing pig oocytes to exogenous interleukin-6 is associated with transcriptomic differences in the resulting blastocysts, with enrichment of developmental signaling pathways.

Frontiers in veterinary science·2026
Same author

Prediction of term preeclampsia using angiogenic biomarkers at 24-29 weeks gestation.

Pregnancy hypertension·2026
Same author

Single motherhood by choice in Sweden: survey of unanticipated support needs and financial challenges.

Reproductive biomedicine online·2026

Related Experiment Video

Updated: Dec 17, 2025

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

623

Birth characteristics in men with infertility.

Susanne Liffner1, Elizabeth Nedstrand1, Marie Bladh1

  • 1Obstetrics and Gynaecology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping SE-581 85, Sweden.

Reproductive Biomedicine Online
|July 1, 2020
PubMed
Summary

Men born small for gestational age face a significantly higher risk of adult male factor infertility. This study highlights the link between intrauterine growth restriction and reduced fertility in men.

Keywords:
IVFLow birth weightMale factor infertilityPreterm birthSmall for gestational age

More Related Videos

Mouse Round Spermatid Injection
08:41

Mouse Round Spermatid Injection

Published on: January 26, 2024

1.2K
Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

3.2K

Related Experiment Videos

Last Updated: Dec 17, 2025

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

623
Mouse Round Spermatid Injection
08:41

Mouse Round Spermatid Injection

Published on: January 26, 2024

1.2K
Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

3.2K

Area of Science:

  • Reproductive Medicine
  • Perinatal Medicine
  • Male Infertility Research

Background:

  • Male factor infertility affects a significant portion of couples seeking fertility treatment.
  • Intrauterine growth restriction (IUGR) and other non-optimal birth characteristics are potential risk factors for later-life health outcomes.
  • The association between specific birth characteristics and adult male infertility requires further investigation.

Purpose of the Study:

  • To investigate the association between low birth weight, prematurity, and being small for gestational age (SGA) with the risk of male factor infertility in adulthood.
  • To determine if non-optimal birth characteristics are more prevalent in men diagnosed with infertility.

Main Methods:

  • A retrospective clinical study involving 892 men diagnosed with infertility and their partners.
  • Utilized data from the Swedish Medical Birth Register for birth weight and gestational age.
  • Included control and reference groups of men born in Sweden during the same periods for comparison.

Main Results:

  • Men with male factor infertility were nearly five times more likely to have been born small for gestational age compared to those with unexplained infertility (OR 4.84).
  • Non-optimal birth characteristics were significantly more common in men with male factor infertility compared to both control (14.8% vs 8.5%) and reference groups (14.8% vs 11.4%).
  • Men with azoospermia also showed a higher prevalence of non-optimal birth characteristics (21.3% vs 12.1%).

Conclusions:

  • The findings suggest a significant association between intrauterine growth restriction and the development of male factor infertility in adulthood.
  • Non-optimal birth characteristics, particularly being small for gestational age, may serve as an indicator for increased risk of male infertility.
  • Further research is warranted to elucidate the mechanisms underlying this association.