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Updated: Dec 17, 2025
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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
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Early microscopic findings in preclinical inflammatory bowel disease
Iago Rodríguez-Lago1, Cynthia Ramírez2, Olga Merino3
1Gastroenterology Department, Hospital de Galdakao, Barrio Labeaga, 48960 Galdakao (Vizcaya), Spain; Biocruces Bizkaia Health Research Institute, Plaza de Cruces, 48903 Barakaldo (Vizcaya), Spain.
Summary
Preclinical Inflammatory Bowel Disease (IBD) has distinct microscopic features. Specific findings like crypt distortion are linked to developing symptoms, offering insights into disease progression.
Area of Science:
- Gastroenterology
- Immunology
- Pathology
Background:
- Inflammatory Bowel Disease (IBD) pathogenesis involves immune responses potentially preceding diagnosis.
- The preclinical phase of IBD remains under-investigated.
- Understanding early IBD markers is crucial for timely intervention.
Purpose of the Study:
- To characterize microscopic findings in preclinical Inflammatory Bowel Disease (IBD).
- To correlate these histologic features with the natural history and progression to symptomatic disease.
Main Methods:
- Retrospective, multicentric study of patients with incidental IBD diagnosis via screening colonoscopy.
- Assessment of 15 histologic items and Geboes score (for UC) in biopsy samples.
- Follow-up to determine the development of gastrointestinal symptoms.
Main Results:
- 110 patients included: 79 Ulcerative Colitis (UC), 24 Crohn's Disease (CD).
- UC: common findings included inflammatory infiltrate and crypt epithelial polymorphs.
- CD: common findings included neutrophilic infiltrate and epithelial irregularity. Crypt distortion and epithelial neutrophil infiltration predicted symptomatic disease development.
Conclusions:
- Preclinical IBD exhibits specific microscopic signatures.
- Histologic findings in early IBD are associated with disease progression.
- Microscopic analysis aids in predicting symptomatic IBD development.
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