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Updated: Dec 17, 2025

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
Published on: January 23, 2018
Monitoring polymer-assisted mechanochemical cocrystallisation through in situ X-ray powder diffraction
Luzia S Germann1, Sebastian T Emmerling1, Manuel Wilke2
1Max Planck Institute for Solid State Research, 70569 Stuttgart, Germany.
Abstract:
Time-resolved mechanochemical cocrystallisation studies have so-far focused solely on neat and liquid-assisted grinding. Here, we report the investigation of polymer-assisted grinding reactions using in situ X-ray powder diffraction, revealing that reaction rate is almost double compared to neat grinding and independent of the molecular weight and amount of the polymer additive used.
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