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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Updated: Dec 17, 2025

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

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A Dual Nanoparticle Delivery Strategy for Enhancing Drug Distribution in Cancerous Tissue.

Ibrahim M Chamseddine¹, Michael Kokkolaras¹

¹Systems Optimization Lab, Department of Mechanical Engineering, McGill University, Montreal, QC H3A 0G4, Canada.

Journal of Biomechanical Engineering

|July 1, 2020

Summary

This summary is machine-generated.

Simultaneously delivering diverse nanoparticle designs improves cancer drug distribution by 14% without reducing accumulation. This nanoparticle-mediated drug delivery offers a promising alternative to chemotherapy.

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Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

Area of Science:

Biomedical Engineering
Nanotechnology
Cancer Therapy

Background:

Traditional chemotherapy faces challenges due to high systemic toxicity.
Tumor tissue architecture complicates nanoparticle drug delivery.
Existing nanoparticle designs present tradeoffs between vascular adherence and tissue drug exposure heterogeneity.

Purpose of the Study:

To investigate simultaneous delivery of multiple nanoparticle designs for enhanced drug distribution.
To optimize nanoparticle design diversity for improved therapeutic outcomes.
To overcome limitations of single-design nanoparticle delivery systems.

Main Methods:

Formulation and solution of numerical optimization problems.
Modeling nanoparticle transport within tumor tissue architecture.
Quantification of drug distribution and nanoparticle accumulation using computational methods.

Main Results:

Simultaneous delivery of diverse nanoparticle designs enhances drug distribution within cancerous tissue.
This approach increases drug distribution by 14% compared to single-design delivery.
Nanoparticle tumoral accumulation is not compromised by using heterogeneous designs.

Conclusions:

Heterogeneous nanoparticle injections represent a viable strategy to improve drug delivery in tumors.
Optimizing nanoparticle design diversity can overcome challenges posed by tumor architecture.
Nanoparticle-mediated drug delivery offers a promising, less toxic alternative to conventional chemotherapy.