Correlation between concentrations of humoral antibodies and vitamin D nutritional status: a survey study

The vitamin D nutritional status and the plasma concentrations of IgG, IgA, IgM and total immunoglobulins were determined in 2052 Saudi subjects. It was observed that females had significantly lower 25-hydroxyvitamin D levels than males and children had lower levels than adults. The mean levels of IgG and IgM were significantly higher in females than in males and those in adults higher than in children. There was a highly significant positive correlation between the concentrations of the circulating form of vitamin D, 25-OHD, and IgG levels in the overall population, in children and in adults. When these groups were classified into males and females the correlation was significant only for females. The significance and importance of this correlation between vitamin D nutritional status and IgG is as yet unknown. The possible clinical relevance of this study's findings are discussed.