Related Experiment Video
Updated: Dec 17, 2025

Pulling Membrane Nanotubes from Giant Unilamellar Vesicles
Published on: December 7, 2017
A quantitative model for the caveolae under cell membrane stretch
Meng Zhang1,2, Anqi Chen3
1Precision Medicine Institute, The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, 510080, China. meng.zhang_china@outlook.com.
Abstract:
In this paper, we proposed a two-state model to quantitatively illustrate the working mechanism of caveolae structure in the regulation of cell membrane stretch. First, we derived the free energy compositions of one caveola in an arbitrary state. This model predicts two local minima for the free energy of one caveola at the completely open and completely closed states at the bottom of a relatively deep curve of free energy at different shape coefficients. The behavior of one caveola is generalized to large number of caveolae in cell membranes using the central limit theory. The dynamic stretching behavior of membrane during a constant-speed tether-pulling experiment is also investigated by making a hypothesis of transition rate between the closed and open states.
More Related Videos
09:29Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
Published on: January 19, 2020
10:02Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions
Published on: May 27, 2021
Related Concept Videos
Mechanisms of Membrane-bending
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
Transport Across the Golgi
Enlargement of the Plasma Membrane
Protein Diffusion in the Membrane
Pinching-off of Coated Vesicles
Tension Response at Adherens Junctions
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...