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Published on: July 5, 2017
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
H Lamdan1, R S Garcia-Lazaro1, N Lorenzo1
1Laboratory of Molecular Oncology, Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, B1876 Bernal, Buenos Aires, Argentina.
Background:
Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties.
Aim:
In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin.
Materials And Methods:
A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated.
Results:
Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells.
Conclusion:
This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro.
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