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Related Experiment Videos

Acute poisoning with gamma-hydroxybutyrate.

Aron C Aronsen, Mette Brekke, Odd Martin Vallersnes

    Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
    |July 1, 2020
    PubMed
    Summary

    Gamma-hydroxybutyrate (GHB) poisoning affects many in Oslo, with half treated at emergency clinics. Hospitalized patients often show severe symptoms like coma and agitation, requiring prompt medical intervention.

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    Area of Science:

    • Emergency Medicine
    • Clinical Toxicology
    • Public Health

    Background:

    • Gamma-hydroxybutyrate (GHB) poisoning is a significant concern, frequently managed at the primary emergency care level in Oslo.
    • Understanding the clinical presentation and outcomes of GHB poisoning is crucial for effective emergency management.

    Purpose of the Study:

    • To describe the clinical characteristics of gamma-hydroxybutyrate (GHB) poisoning.
    • To compare patients hospitalized with GHB poisoning to those discharged from the emergency department.

    Main Methods:

    • Retrospective registration of 329 patients diagnosed with GHB poisoning at Oslo Accident and Emergency Outpatient Clinic (October 2013 - September 2015).
    • Inclusion criteria focused on cases where GHB was used as an intoxicant.
    • Data collected included patient demographics, co-intoxicants, level of consciousness, and disposition (hospitalization vs. discharge).

    Main Results:

    • A total of 329 GHB poisoning cases were identified, with a median age of 30 years and 69% males.
    • Reduced consciousness (69%), coma (14%), and agitation (36%) were common symptoms.
    • Hospitalized patients (48%) were significantly more likely to be comatose (23% vs. 5%) and agitated (43% vs. 28%) compared to discharged patients.

    Conclusions:

    • Approximately half of GHB poisoning cases were managed solely at the A&E clinic level.
    • Patients requiring hospitalization often presented with severe symptoms necessitating immediate transfer from the emergency department.

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