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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

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The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
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Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

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Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
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Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

51.8K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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Related Experiment Video

Updated: Dec 17, 2025

Generating Whole Bacterial Genomes from Clinical Samples using a Target Enrichment Workflow
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Generating Whole Bacterial Genomes from Clinical Samples using a Target Enrichment Workflow

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Genomics against gonorrhoea.

Nicholas Medland1

  • 1Kirby Institute, University of New South Wales, Sydney, Australia.

Elife
|July 1, 2020
PubMed
Summary

Whole genome sequencing offers a powerful tool for the early detection of drug-resistant gonorrhoea. This approach aids in identifying emerging resistance patterns to combat the spread of this infection.

Area of Science:

  • Microbiology
  • Genomics
  • Public Health

Background:

  • Neisseria gonorrhoeae is a significant public health concern.
  • Antimicrobial resistance in gonorrhoea is a growing global threat.
  • Current surveillance methods may not be sufficient for rapid detection of novel resistance.

Purpose of the Study:

  • To evaluate the utility of whole genome sequencing (WGS) for gonorrhoea surveillance.
  • To assess the potential of WGS in identifying new drug-resistant strains.
  • To inform the development of enhanced gonorrhoea control strategies.

Main Methods:

  • Utilizing whole genome sequencing data from gonorrhoea isolates.
  • Analyzing genomic data to identify known and novel antimicrobial resistance genes.
Keywords:
Neisseria gonorrhoeaeantibiotic resistancediagnosticepidemiologyglobal healthinfectious diseasemicrobiologysurveillance

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  • Comparing WGS-based detection with traditional phenotypic susceptibility testing.

    • Main Results:

    • Whole genome sequencing enables comprehensive profiling of gonorrhoea strains.
    • Genomic surveillance can identify emerging resistance mechanisms earlier than conventional methods.
    • WGS facilitates tracking the transmission of resistant gonorrhoea strains.

    Conclusions:

    • Whole genome sequencing is a valuable tool for real-time gonorrhoea surveillance.
    • Implementing WGS-based strategies can improve the early detection of drug resistance.
    • Enhanced surveillance is crucial for effective gonorrhoea treatment and prevention efforts.