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Related Experiment Videos

Amyloid AA protein. Cellular distribution and appearance.

S Watanabe, E Jaffe, S Pollock

    American Journal of Clinical Pathology
    |June 1, 1977
    PubMed
    Summary

    Researchers studied the cellular origin of AA protein in secondary amyloid deposits. Findings suggest AA protein may be an immunoprotein, possibly originating from plasma cells in lymphoid tissues.

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    Area of Science:

    • Immunology
    • Pathology
    • Cell Biology

    Background:

    • AA protein is a primary component of secondary amyloid deposits.
    • The cellular origin and distribution of AA protein remain incompletely understood.

    Purpose of the Study:

    • To investigate the cellular distribution of AA protein.
    • To explore the potential cellular origin of AA protein in secondary amyloidosis.

    Main Methods:

    • Indirect immunofluorescence was employed on various human tissues.
    • Specific anti-AA immunoglobulin and FITC-goat anti-rabbit IgG were used.
    • Double staining with rhodamine-labeled anti-IgG was performed.

    Main Results:

    • Positive cells for AA protein were most frequently found in reactive lymphoid tissues.
    • Tonsils showed the highest concentration of positive cells, followed by spleens.
    • Cellular morphology and distribution suggested a plasmacytic origin.
    • Immunoglobulin G (IgG) was detected within some of these AA-positive cells.

    Conclusions:

    • The data indicate that AA protein may function as an immunoprotein.
    • While suggestive, definitive assignment of AA protein origin to plasma cells requires further kinetic data.

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