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Related Experiment Videos

Single photon emission computerized tomography during and between seizures.

W Lang1, I Podreka, E Suess

  • 1Abteilung für Neuronulkeare Medizin, Neurologische Universitätsklinik, Vienna, Austria.

Journal of Neurology
|May 1, 1988
PubMed
Summary
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99mTc-HM-PAO brain SPECT revealed increased blood flow during seizures, persisting days later. Over weeks, seizure foci showed decreased blood flow, highlighting SPECT

Area of Science:

  • Neurology
  • Nuclear Medicine
  • Radiology

Background:

  • Epilepsy diagnosis relies on clinical symptoms and electroencephalography (EEG).
  • Assessing regional cerebral blood flow (rCBF) can help localize seizure foci.
  • Technetium-99m hexamethyl-propyleneamineoxime (99mTc-HM-PAO) SPECT is a tool for brain imaging.

Observation:

  • Brain SPECT imaging was performed on three patients during ictal and interictal states.
  • Increased relative cerebral blood flow was observed in seizure foci and spreading areas.
  • SPECT studies were conducted at different time points post-seizure.

Findings:

  • Ictal SPECT showed increased rCBF correlating with clinical seizure symptoms.
  • Interictal SPECT, even without clinical signs, revealed persistent increased rCBF in seizure foci.

Related Experiment Videos

  • Delayed SPECT (2-6 weeks post-seizure) demonstrated a shift from increased to decreased rCBF in the seizure focus.

    • Implications:

    • 99mTc-HM-PAO brain SPECT is valuable for identifying seizure onset zones.
    • SPECT provides dynamic insights into cerebral blood flow changes related to seizures.
    • Brain SPECT offers a complementary diagnostic tool for epilepsy, especially for interictal changes undetectable by EEG.