Related Experiment Video

Updated: Sep 25, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

[Pathological classification of malignant lymphoma]

K Mukai1

  • 1Pathology Division, National Cancer Research Institute.

Gan No Rinsho. Japan Journal of Cancer Clinics
|April 1, 1988
PubMed

Insights

Accurate classification of malignant lymphomas, including Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL), is crucial for effective treatment. Current non-Hodgkin's lymphoma classifications need improvement to integrate new scientific understanding for better clinical application.

Area of Science:

  • Oncology
  • Hematology
  • Pathology

Context:

  • Accurate diagnosis and classification of malignant lymphomas are critical for guiding patient treatment strategies.
  • Distinguishing between Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) is essential due to their differing clinical behaviors and therapeutic responses.
  • Existing classification systems for non-Hodgkin's lymphoma (NHL) primarily rely on morphology and require enhancement to incorporate modern biological insights.

Purpose:

  • To highlight the importance of precise lymphoma classification in clinical practice.
  • To underscore the limitations of current non-Hodgkin's lymphoma (NHL) classification systems.
  • To advocate for the development of improved, histogenetically accurate, and clinically relevant lymphoma classifications.

Summary:

  • Malignant lymphoma classification is pivotal for treatment selection, necessitating clear differentiation between Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL).
  • While Hodgkin's disease (HD) subtypes exist, their clinical significance is limited compared to the need for advanced classification of non-Hodgkin's lymphoma (NHL).
  • Current non-Hodgkin's lymphoma (NHL) classifications, largely morphology-based, must evolve to integrate current understanding of lymphoma cell biology for improved accuracy and clinical utility.

Impact:

  • Facilitates more targeted and effective therapeutic interventions for lymphoma patients.
  • Drives the development of next-generation lymphoma classification systems.
  • Enhances the precision of oncological and hematological diagnoses, improving patient outcomes.

More Related Videos

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories: