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Updated: Dec 17, 2025
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Heteroarene-tethered Functionalized Alkyne Metamorphosis
Debojyoti Bag1, Sanghapal D Sawant1
1Laboratory 212, Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine Jammu, Canal Road, Jammu, Jammu and Kashmir, 180001, India.
Heteroarene-tethered functionalized alkynes are versatile building blocks for creating complex molecules. This review details their transformations, focusing on efficient synthesis of heterocyclic scaffolds.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Heteroarene-tethered functionalized alkynes are key intermediates.
- Their utility in synthesizing complex heterocyclic scaffolds is significant.
Purpose of the Study:
- To provide a comprehensive review of synthetic transformations involving heteroarene-tethered functionalized alkynes.
- To highlight recent advancements in the last decade.
Main Methods:
- Survey of synthetic methodologies.
- Discussion of dearomatizing spirocyclizations and cascade reactions.
- Analysis of reaction mechanisms and scope.
Main Results:
- Demonstration of atom and step-economic synthesis of complex heterocycles.
- Highlighting key transformations like spirocyclizations.
- Compilation of applications in natural product synthesis.
Conclusions:
- Heteroarene-tethered functionalized alkynes offer efficient routes to complex heterocyclic structures.
- Further exploration of their reactivity and applications is warranted.
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