Prognostic value and association of systemic inflammation for patients with stage IV gastric cancer
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Updated: Dec 17, 2025
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Published on: February 16, 2024
1Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
Objective:
The present study is aimed at investigating the prognostic value and association of systemic inflammation (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and lymphocyte-to-monocytes ratio) for patients with stage IV gastric cancer.
Methods:
In this retrospective study, patients with stage IV gastric cancer between January 2008 and December 2017 were included. A summary was performed on clinicopathological characteristics and a multivariate cox regression analysis was performed to identify the prognostic factors.
Results:
304 patients with stage IV gastric cancer were included in the study. On multivariate analysis, the systemic chemotherapy (p < .001), the jaundice (p = .004), the high neutrophil-to-lym- phocyte ratio (p = .005) and the high platelet-to-lymphocyte ratio (p = .041) were independent prognostic factors for patients with stage IV gastric cancer.
Conclusion:
As systemic inflammation response markers, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are significantly associated with OS for stage IV gastric cancer patients. Systemic chemotherapy shows a clear overall survival benefit in patients with stage IV gastric cancer and Jaundice indicates poor overall survival.
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