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Related Experiment Videos

Drugs or Mechanical Devices for Obstructive LUTS?

Evangelos N Symeonidis1, Petros Sountoulides1

  • 11st Department of Urology, Aristotle University of Thessaloniki, "G. Gennimatas" General Hospital, Thessaloniki, Greece.

Current Drug Targets
|July 1, 2020
PubMed
Summary
This summary is machine-generated.

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Benign prostate obstruction (BPO) causing lower urinary tract symptoms (LUTS) affects many globally. Minimally invasive surgical therapies (MISTs) offer advantages over traditional treatments, though long-term efficacy requires further study.

Area of Science:

  • Urology
  • Surgical Innovation

Background:

  • Lower urinary tract symptoms (LUTS) due to benign prostate obstruction (BPO) are highly prevalent worldwide.
  • Current management includes medical and surgical options, with limited advancements in drug therapy.
  • Conventional transurethral resection of the prostate (TURP) has been the standard surgical approach.

Purpose of the Study:

  • To provide a narrative review of current literature.
  • To indirectly compare the efficacy and safety of medical therapies versus minimally invasive surgical therapies (MISTs) for obstructive LUTS.
  • To assess the advantages of MISTs regarding sexual function preservation and morbidity.

Main Methods:

  • Literature review and narrative synthesis.
  • Indirect comparative assessment of available studies on medical treatments and MISTs.
Keywords:
BPHLUTSbenign prostate obstructiondrugsmechanical devicesminimally invasive therapiespharmacotherapy

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  • Focus on outcomes related to symptom improvement, sexual function, and safety profiles.

    • Main Results:

    • Minimally invasive surgical therapies (MISTs) have emerged with potential benefits over TURP.
    • MISTs may offer better preservation of sexual function and reduced morbidity.
    • Long-term efficacy and durability of MISTs compared to drug therapy remain under investigation.

    Conclusions:

    • MISTs represent a significant advancement in managing obstructive LUTS secondary to BPO.
    • Further research is needed to establish the long-term effectiveness and durability of MISTs.
    • MISTs show promise for improved patient outcomes and quality of life.