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Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
Published on: August 30, 2020
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Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study.
Chiara Robba1,2, Raffaele Aspide3, Marianna Pegoli3
1Department of Anesthesia and Intensive Care, Policlinico San Martino, IRCCS for Oncology and Neuroscience, Genova.
Journal of Neurosurgical Anesthesiology
|July 1, 2020
Summary
Pituitary dysfunction is frequent following aneurysmal subarachnoid hemorrhage (aSAH). However, this endocrine abnormality does not impact patient outcomes at six to twelve months post-event.
Area of Science:
- Neuroendocrinology
- Neurosurgery
- Critical Care Medicine
Background:
- Pituitary dysfunction following aneurysmal subarachnoid hemorrhage (aSAH) is not well understood.
- The impact of post-aSAH pituitary abnormalities on patient outcomes requires further investigation.
Purpose of the Study:
- To determine the prevalence of pituitary dysfunction after aSAH.
- To assess the effect of pituitary dysfunction on clinical outcomes in aSAH patients.
Main Methods:
- Prospective cohort study of adult aSAH patients admitted to the ICU across three centers.
- Endocrine function testing in the acute (≤48h), subacute (1-3 weeks), and chronic (6-12 months) phases post-aSAH.
- Clinical outcomes assessed at 6-12 months using the modified Rankin Scale.
Main Results:
- Fifty-six patients were included in the study.
- High prevalence of pituitary dysfunction observed: 92.3% acute, 83.3% subacute, and 83.3% chronic phases.
- Pituitary-gonadal axis dysfunction was the most common abnormality; no correlation found between pituitary dysfunction and clinical outcome.
Conclusions:
- Pituitary dysfunction is a common complication after aSAH.
- Post-aSAH pituitary dysfunction does not appear to influence clinical outcomes at 6 to 12 months.
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