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Factors Affecting Drug Distribution: Organ Perfusion Rate

Factors Affecting Drug Distribution: Organ Perfusion Rate

Drug distribution within the body is a complex process influenced by several factors, including perfusion rate, the rate at which the bloodstream transports drugs to tissue. This limitation becomes particularly significant when dealing with highly lipophilic drugs. In such cases, the rate at which the drug can move across membranes is crucial, and if the membrane is highly permeable to the drug, distribution becomes rate-limited by perfusion.
Perfusion rate-limited distribution relies on the...

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Related Experiment Video

Updated: Dec 16, 2025

Normothermic Ex Vivo Liver Machine Perfusion in Mouse

Normothermic Ex Vivo Liver Machine Perfusion in Mouse

Published on: September 25, 2023

Prolonged Organ Perfusion

Jennifer S McLeod¹, Gabe E Owens², Jonathan Haft¹

¹Extracorporeal Life Support Laboratory, Department of Surgery, Michigan Medicine, Ann Arbor, Michigan.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)

|July 1, 2020

Summary

No abstract available in PubMed .

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