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Hypokalemic, metabolic alkalosis induced by high-dose ampicillin sodium
Abstract:
A case of hypokalemic metabolic alkalosis precipitated by high-dose intravenous ampicillin sodium is discussed. Cases of hypokalemic metabolic alkalosis attributable to ampicillin sodium have not been reported previously. There have been reports of this phenomenon associated with high doses of penicillin sodium and carbenicillin disodium. The possible mechanism of antibiotic-induced hypokalemic metabolic alkalosis is discussed. It is suggested that most cases of antibiotic-induced hypokalemia respond to oral or intravenous potassium chloride.
Insights
High-dose ampicillin sodium can cause hypokalemic metabolic alkalosis, a condition not previously reported for this antibiotic. This adverse effect, similar to penicillin and carbenicillin, often resolves with potassium chloride treatment.
Area of Science:
- Pharmacology
- Nephrology
- Internal Medicine
Background:
- Antibiotics like penicillin and carbenicillin have been associated with metabolic alkalosis.
- The specific link between ampicillin sodium and this condition was previously undocumented.
Observation:
- A patient developed hypokalemic metabolic alkalosis after receiving high-dose intravenous ampicillin sodium.
Findings:
- This case represents the first reported instance of ampicillin sodium inducing hypokalemic metabolic alkalosis.
- The study discusses potential mechanisms for antibiotic-induced electrolyte disturbances.
Implications:
- Clinicians should be aware of this potential adverse effect of ampicillin sodium.
- Prompt administration of potassium chloride may effectively manage antibiotic-induced hypokalemia and metabolic alkalosis.