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Psoriatic spondyloarthropathy: a long term prospective study
J G Hanly1, M L Russell, D D Gladman
1University of Toronto Rheumatic Disease Unit, Women's College Hospital, Canada.
Annals of the Rheumatic Diseases
|May 1, 1988
Summary
Psoriatic spondyloarthropathy patients show radiological disease progression, including syndesmophyte formation and sacroiliitis. However, this progression is clinically silent, with no significant impact on spinal mobility or symptoms.
Area of Science:
- Rheumatology
- Immunology
- Radiology
Background:
- Psoriatic spondyloarthropathy is a chronic inflammatory condition affecting the spine.
- Understanding disease progression is crucial for patient management.
Purpose of the Study:
- To prospectively assess the clinical and radiological progression of psoriatic spondyloarthropathy.
- To evaluate the impact of disease progression on spinal mobility and symptoms.
Main Methods:
- Prospective monitoring of 52 patients over a mean of 57 months.
- Comprehensive assessment of clinical features and serial radiographic evaluation.
- Measurement of spinal mobility and assessment of pain and tenderness.
Main Results:
- Significant increase in syndesmophyte formation and sacroiliitis observed radiologically.
- No significant increase in inflammatory neck/back pain, stiffness, or sacroiliac tenderness.
- No significant changes in thoracolumbar spine mobility measurements.
- HLA-B27 status did not influence disease progression.
Conclusions:
- Psoriatic spondyloarthropathy exhibits radiological progression.
- This radiological progression is clinically silent and does not impair spinal mobility.
- Further research may explore mechanisms behind this dissociation.