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Related Experiment Video

Updated: Dec 16, 2025

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
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Amyloid Proteins and Peripheral Neuropathy.

Mohammed M H Asiri1,2, Sjoukje Engelsman1, Niels Eijkelkamp1

  • 1Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.

Cells
|July 2, 2020
PubMed
Summary
This summary is machine-generated.

Amyloid protein deposits in tissues are linked to painful peripheral neuropathy. This review explores how these proteins cause nerve damage in both rare and common diseases, suggesting a shared pathway for peripheral amyloid neuropathies.

Keywords:
amyloid neuropathiesamyloid proteinsamyloidosischronic painperipheral neuropathytype 2 diabetes mellitus

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Area of Science:

  • Neurology
  • Pathology
  • Molecular Biology

Background:

  • Peripheral neuropathy affects millions globally, stemming from diverse conditions like diabetes and inflammatory diseases.
  • A common feature across these conditions is the deposition of amyloid-forming proteins in tissues.
  • These amyloid deposits can lead to nerve damage and dysfunction, contributing to neuropathy.

Purpose of the Study:

  • To review the pathogenic mechanisms of amyloid protein contribution to peripheral neuropathy.
  • To explore the potential role of amyloid in common diseases not currently classified as amyloid neuropathies.
  • To propose a unifying pathogenic pathway for peripheral amyloid neuropathies.

Main Methods:

  • Review of current literature on pathogenic mechanisms in inherited and acquired amyloid neuropathies.
  • Analysis of histopathological findings linking amyloid deposits to nerve damage.
  • Comparative analysis of molecular and cell biological defects across different amyloid-forming protein diseases.

Main Results:

  • Amyloid-forming proteins are implicated in nerve damage across various neuropathies.
  • Similar molecular and cell biological defects are observed due to different amyloid protein aggregations.
  • A potential common pathogenic pathway for peripheral amyloid neuropathies is identified.

Conclusions:

  • Amyloid protein deposition is a significant factor in peripheral neuropathy development.
  • Understanding shared mechanisms can lead to new diagnostic and therapeutic strategies.
  • The concept of 'peripheral amyloid neuropathies' unifies diverse disease presentations.