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Close Correlation between Frailty and Depressive State in Chronic Liver Diseases.
Hiroki Nishikawa1,2, Kazunori Yoh1, Hirayuki Enomoto1
1Department of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
Medicina (Kaunas, Lithuania)
|July 2, 2020
Summary
This study reveals a strong link between frailty and depression in chronic liver disease patients. Addressing frailty should consider both physical and mental health aspects for better patient outcomes.
Area of Science:
- Geriatrics
- Hepatology
- Psychiatry
Background:
- Limited data exists on the connection between depression and frailty in chronic liver disease (CLD) patients.
- Frailty is a clinical syndrome characterized by unintended weight loss, exhaustion, muscle weakness, slow walking speed, and low physical activity.
Purpose of the Study:
- To investigate the relationship between frailty and depression, assessed using the Beck Depression Inventory-2nd edition (BDI-II), in patients with CLD.
Main Methods:
- Frailty was assessed using a standardized definition (three or more criteria: weight loss, exhaustion, weakness, slow gait, low activity).
- Depressive state was defined as a BDI-II score of 11 or higher.
- The study included 340 CLD patients with a median age of 65.0 years.
Main Results:
- Frailty was identified in 12.9% of patients, prefrailty in 53.5%, and 33.5% were robust.
- The prevalence of depressive states increased with frailty severity: 3.51% in robust, 30.77% in prefrail, and 54.55% in frail patients.
- A significant positive correlation was found between frailty score and BDI-II score (r = 0.5855, p < 0.0001).
Conclusions:
- A significant correlation exists between frailty and depression in CLD patients.
- Interventions for frailty in CLD should encompass both physiological and psychological approaches.
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