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Closable Valves and Channels for Polymeric Microfluidic Devices.

Charles P Clark1, M Shane Woolf1, Sarah L Karstens1

  • 1Department of Chemistry, University of Virginia, Charlottesville, VA 22903, USA.

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|July 2, 2020
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Summary
This summary is machine-generated.

This study presents three novel methods for sealing microfluidic channels in polymeric devices. These techniques ensure precise fluid control, preventing contamination and enabling advanced bioanalytical applications.

Keywords:
centrifugalclosable valvingcontact heatingexpandable foammicrofluidicredeposition

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Area of Science:

  • Biotechnology
  • Materials Science
  • Chemical Engineering

Background:

  • Microfluidic systems require precise fluid control for various bioanalytical applications.
  • Existing methods for closing microfluidic channels can be complex or lack robustness.

Purpose of the Study:

  • To develop and evaluate three distinct techniques for effectively closing valves and channels in multilayer, centrifugally driven polymeric microfluidic devices.
  • To demonstrate the utility of these sealing methods for enhancing fluidic control and enabling advanced microfluidic operations.

Main Methods:

  • Utilizing expanding polyurethane foam to physically block channels.
  • Applying direct contact heating to induce substrate modification and sealing.
  • Employing xerographic toner redeposition via chloroform solvation and evaporation for channel closure.

Main Results:

  • All three methods successfully closed previously open fluidic pathways after critical unit operations.
  • The techniques demonstrated effective prevention of backflow and maintenance of pressurized chambers.
  • Sample fractionation without cross-contamination was facilitated by the implemented sealing strategies.

Conclusions:

  • The developed sealing techniques offer robust solutions for precise fluidic control in microfluidic devices.
  • These methods are adaptable for integration into a wide range of microfluidic bioanalytical systems.
  • The ability to reliably close channels enhances the functionality and applicability of centrifugal polymeric microfluidics.