Related Experiment Video
Updated: Dec 16, 2025
Laparoscopic-Assisted Seldinger Technique for Peritoneal Dialysis Catheter Insertion
Published on: May 23, 2025
Relapsing peritonitis and taurolidine peritoneal catheter lock: One center experience
R Haridian Sosa Barrios1,2, Marta Álvarez Nadal1, Víctor Burguera Vion1,2
1Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
Background:
Relapsing peritonitis due to the development of a biofilm in the catheter's lumen remains an important complication of peritoneal dialysis therapy that endangers technique continuity. Taurolidine catheter lock has proven efficient reducing infection rates in permanent hemodialysis catheters based on its biocidal activity and biofilm detachment effect. Efficacy evidence on its use in peritoneal dialysis catheters is lacking.
Methods:
We retrospectively analyzed all relapsing peritonitis episodes from June 2018 until October 2019 in our center. Patients were identified and data were collected from our electronic renal registry and patient's records.
Results:
Six patients were identified during the study period. Most patients (66.6%) were on automated peritoneal dialysis and the median duration of peritoneal dialysis before the episode of taurolidine was started was 43.66 ± 29.64 months. Mean taurolidine doses were 10 (range: 9-11) and 83.3% (five patients, with peritonitis caused by Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Corynebacterium propinquum) had a favorable response and microbial eradication without relapses after taurolidine treatment. Only one patient relapsed by the same organism (Corynebacterium amycolatum) due to non-adherence to the antibiotic treatment prescribed. None of the patients experienced any relevant adverse events, with only two out of six presenting mild transient abdominal discomfort.
Conclusion:
We believe that peritoneal catheter taurolidine lock could be considered in cases of relapsing or refractory peritonitis, as it could prevent catheter removal and permanent switch to hemodialysis in selected cases, although literature is scarce and further studies are needed.
Insights
Taurolidine catheter lock shows promise in treating relapsing peritonitis in peritoneal dialysis patients, effectively clearing infections and preventing relapses in most cases with minimal side effects.
Area of Science:
- Nephrology
- Infectious Diseases
Background:
- Relapsing peritonitis due to biofilm in peritoneal dialysis (PD) catheters is a significant complication.
- Taurolidine is effective for hemodialysis catheters, but its use in PD is understudied.
Purpose of the Study:
- To evaluate the efficacy of taurolidine catheter lock in treating relapsing peritonitis in peritoneal dialysis patients.
Main Methods:
- Retrospective analysis of relapsing peritonitis episodes from June 2018 to October 2019.
- Data collected from electronic renal registry and patient records.
Main Results:
- Six patients with relapsing peritonitis were identified.
- 83.3% of patients achieved microbial eradication without relapse after taurolidine treatment.
- No significant adverse events were reported, with only mild transient abdominal discomfort in two patients.
Conclusions:
- Taurolidine catheter lock may be a viable option for refractory or relapsing peritonitis in PD.
- It could potentially prevent catheter removal and conversion to hemodialysis.
- Further research is needed due to limited current literature.
Related Concept Videos
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
01:25Peritoneal Dialysis III: Nursing Management
01:30Peritoneal Dialysis I: Introduction and Procedure