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Generation of LAK cells depends on the age of LAK cell precursor donors
Age-related changes in generation of lymphokine-activated killer cells were examined in the experimental system of B10 murine effector cells activated with human recombinant interleukin 2 that were allowed to react with a panel of murine and human target cell lines. The percentage of specific 51Cr release displayed by the LAK cells derived from 6- and 12-month-old donors was consistently lower than that displayed by the 2-month-old mice. However, even the LAK cells from 12-month-old mice still showed a significant cytolytic activity.
Age-related changes in generation of lymphokine-activated killer cells were examined in the experimental system of B10 murine effector cells activated with human recombinant interleukin 2 that were allowed to react with a panel of murine and human target cell lines. The percentage of specific 51Cr release displayed by the LAK cells derived from 6- and 12-month-old donors was consistently lower than that displayed by the 2-month-old mice. However, even the LAK cells from 12-month-old mice still showed a significant cytolytic activity.