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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Microbiome definition re-visited: old concepts and new challenges
Gabriele Berg1, Daria Rybakova2, Doreen Fischer3
1Environmental Biotechnology, Graz University of Technology, Graz, Austria. gabriele.berg@tugraz.at.
Microbiome
|July 2, 2020
Summary
Microbiome research lacks a clear definition and standardized practices. This work proposes an updated definition and recommendations to improve study consistency and knowledge transfer in microbiome science.
Area of Science:
- Microbiology
- Ecology
- Genomics
Background:
- The rapidly expanding field of microbiome research necessitates a clear, unified definition and standardized methodologies.
- A recent international expert workshop and survey highlighted critical gaps in current microbiome research practices.
Discussion:
- The article distinguishes between 'microbiome' and 'microbiota,' offering a refined definition of microbiome.
- It discusses key aspects including microbiota composition, microbiome dynamics, network stability, core microbiomes, keystone species, and microbe-host co-evolution.
Key Insights:
- Proposes an updated, comprehensive definition of 'microbiome' based on historical context and recent advancements.
- Recommends novel concepts for standardizing microbiome studies, addressing heterogeneity, stability, and interactions.
Outlook:
- Standardized microbiome definitions and practices will accelerate knowledge transfer from basic science to practical applications.
- Understanding microbiomes is crucial for addressing planetary health challenges driven by anthropogenic changes.
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