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Risk factors for bleeding in haemato-oncology patients-a nested case-control study: The BITE study protocol (Bleeding
Loes L Cornelissen1,2,3, Camila Caram-Deelder1,3, Johanna G van der Bom1,3
1Jon J van Rood Center for Clinical Transfusion Research, Sanquin/LUMC, Leiden, The Netherlands.
BMJ Open
|July 2, 2020
Summary
This study investigates bleeding risk factors in cancer patients receiving platelet transfusions. Identifying these factors can optimize transfusion strategies and reduce bleeding events in thrombocytopenic patients.
Area of Science:
- Hematology
- Oncology
- Clinical Research
Background:
- Hematologic cancer patients often receive prophylactic platelet transfusions based on platelet counts to prevent bleeding.
- Despite transfusions, many patients still experience bleeding events.
- Improved understanding of bleeding risk factors is crucial for optimizing transfusion policies.
Purpose of the Study:
- To identify clinical conditions and biomarkers associated with clinically relevant bleeding in hematologic cancer patients.
- To establish bleeding risk profiles for personalized transfusion strategies.
- To optimize future prophylactic platelet transfusion policies.
Main Methods:
- A matched case-control study nested within a cohort of hematologic cancer patients in the Netherlands.
- Data collection includes variables from a source population, followed for bleeding events.
- Detailed clinical data is collected from cases and frequency-matched controls.
Main Results:
- The study aims to calculate bleeding incidences in various subgroups.
- Conditional logistic regression will be used to analyze the association between potential risk factors and bleeding.
- Pre-results indicate an ongoing investigation into bleeding risk factors.
Conclusions:
- Identifying bleeding risk factors is essential for improving patient outcomes in hematologic oncology.
- This research will contribute to evidence-based transfusion strategies.
- The findings will aid in developing more effective bleeding prevention protocols.
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