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Related Experiment Video

Updated: Dec 16, 2025

Comet Assay to Quantify DNA Damage in FLT3 Mutant-expressing 32D Cells after Exposure to Type I and Type II FLT3 Inhibitors

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Filgrastim induced thrombocytopenia.

Ghazal Kango¹, Faysal Haroun²

¹George Washington University, Washington, District of Columbia, USA gkango@gwu.edu.

BMJ Case Reports

|July 2, 2020

Summary

Severe thrombocytopenia occurred after filgrastim use in a patient undergoing stem cell harvest. This drug-induced thrombocytopenia (DITP) led to the abortion of the planned autologous stem cell transplant.

Keywords:

Haematology (incl blood transfusion)cancer - see oncology haematology (drugs and medicines)malignant and benign haematology unwanted effects / adverse reactions

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Area of Science:

Hematology
Pharmacology
Oncology

Background:

Drug-induced thrombocytopenia (DITP) is a serious adverse event characterized by low platelet counts.
Filgrastim is commonly used to stimulate white blood cell production during stem cell transplantation.
Multiple myeloma patients undergoing autologous stem cell transplantation (ASCT) may receive filgrastim for peripheral blood progenitor cell harvest.

Observation:

A case study details a patient experiencing severe thrombocytopenia following filgrastim administration.
The thrombocytopenia resolved upon discontinuation of filgrastim, suggesting a drug-induced etiology.
This reaction occurred during the stem cell harvest phase for an elective ASCT.

Findings:

The patient exhibited classic signs of DITP, including severe thrombocytopenia after filgrastim exposure.
Reproducibility of thrombocytopenia upon drug re-exposure is a key diagnostic criterion for DITP.
The patient's case demonstrated suggestive features of DITP linked to filgrastim.

Implications:

The potential for filgrastim to induce thrombocytopenia must be considered in clinical practice.
DITP can necessitate the alteration or cessation of planned treatments like ASCT.
This case highlights the importance of vigilant monitoring for adverse drug reactions during complex cancer therapies.